Premium
Increase of Catecholamines in Mouse Brain by Systemic Administration of γ‐Glutamyl L‐3,4‐Dihydroxyphenylalanine
Author(s) -
Ichinose Hiroshi,
Togari Akifumi,
Suzuki Hidenori,
Kumagai Hideaki,
Nagatsu Toshiharu
Publication year - 1987
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1987.tb00982.x
Subject(s) - homovanillic acid , dihydroxyphenylalanine , dopamine , endocrinology , catecholamine , medicine , chemistry , endogeny , levodopa , norepinephrine , catechol o methyl transferase , acetic acid , in vitro , pharmacology , parkinson's disease , biochemistry , serotonin , disease , allele , receptor , gene
We investigated the effect of systemic administration of γ‐glutamyl L‐3,4‐dihydroxyphenylalanine (γ‐Glu‐DOPA) on catecholamine contents in the brain. γ‐Glu‐DOPA was transformed to dopamine (DA) in vitro with brain homogenate by the sequential action of γ‐glutamyl transpeptidase and aromatic L‐amino acid decarboxylase. Intraperitoneal injection of γ‐Glu‐DOPA to mice increased DA markedly and noradrenaline (NA) moderately in the brain. The increase of endogenous DA was followed by elevation of the main DA metabolites (3,4‐dihydroxyphenyl‐acetic acid and homovanillic acid). These increases were in a dose‐dependent manner. The maximal elevation of DA was observed within 30 min after administration of γ‐Glu‐DOPA, but a substantial increase of NA was observed 2 h after the administration. These results suggest that γ‐Glu‐DOPA may be applicable to the treatment of Parkinson's disease.