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Regulation of Dopamine Release from Interplexiform Cell Processes in the Outer Plexiform Layer of the Carp Retina
Author(s) -
O'Connor Patricia M.,
Zucker Charles L.,
Dowling John E.
Publication year - 1987
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1987.tb00980.x
Subject(s) - outer plexiform layer , dopamine , inner plexiform layer , retina , neuroscience , neurotransmitter , chemistry , biology , central nervous system
The 7‐aminobutyric acid (GABA) antagonists bicuculline and picrotoxin stimulate a four‐ to fivefold increase in endogenous dopamine release from isolated intact carp retina. The release evoked by these agents is Ca 2+ dependent, a finding suggesting a vesicular release. Using light microscopic autoradiography, we have localized the sites of dopamine release to the dopaminergic interplexiform cell processes of the outer plexiform layer, which synapse onto horizontal cells. Our findings support previous suggestions that the dopaminergic interplexiform cells receive GABAergic inhibitory input and that the effects of GABA antagonists on horizontal cells are mediated by dopamine release from the interplexiform cells.