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Changes in Composition of Endoneurial and Perineurial Fatty Acids During Glycerol‐Induced Wallerian Degeneration and Regeneration in the Sciatic Nerve of the Adult Rat
Author(s) -
Fressinaud C.,
Vallat J. M.,
Durand J.,
ArchambeaudMouveroux F.,
Rigaud M.
Publication year - 1987
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1987.tb00963.x
Subject(s) - endoneurium , wallerian degeneration , perineurium , polyunsaturated fatty acid , sciatic nerve , glycerol , regeneration (biology) , adipose tissue , chemistry , anatomy , degeneration (medical) , medicine , endocrinology , biology , biochemistry , fatty acid , pathology , microbiology and biotechnology , peripheral nerve
Intraneural injection of pure glycerol induces Wallerian degeneration with subsequent regeneration. In agreement with other reports, we observed an increase in endoneurial polyunsaturated fatty acids 8 days after the glycerol injection. Levels then fell until day 30. After a period of 5 months, there was an increase in C18:2(n‐6) in the intrafascicular tissue, concomitant with a marked fall in this fatty acid in the remaining extrafascicular perineurium. The rise in C18:2(n‐6) in endoneurium correlated with infiltration of this tissue by perineurial cells. Interactions between perineurium and endoneurium during nerve regeneration are discussed.