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5,5‐Diphenylhydantoin Antagonizes Neurochemical and Behavioral Effects of p, p' ‐DDT but Not of Chlordecone
Author(s) -
Tilson Hugh A.,
Hudson P. M.,
Hong J. S.
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb13101.x
Subject(s) - brainstem , chemistry , neurochemical , phenytoin , medicine , endocrinology , glycine , spinal cord , glutamate receptor , amino acid , biochemistry , biology , epilepsy , neuroscience , receptor
Rats were given 75 mg/kg of 5,5‐diphenylhydantoin (phenytoin) or vehicle 30 min prior to 75 mg/kg of 1, 1, 1‐trichloro‐bis( p ‐chlorophenyl)ethane ( p, p' ‐DDT) (p.o.) or chlordecone (i.p.) and tremor was measured 12 h later. Rats were then killed, and regional brain levels of biogenie amines and their acid metabolites and amino acids were determined. Pretreatment with phenytoin significantly attenuated the tremor produced by p, p' ‐DDT but enhanced that produced by chlordecone. p, p' ‐DDT had significant effects on the levels of asparate, glutamate, 5‐hydroxyindoleacetic acid (5‐HIAA), and 3‐methoxy‐4‐hydroxyphenylglycol (MHPG), whereas chlordecone increased glycine, 5‐HIAA, and MHPG levels. Pretreatment with phenytoin blocked p.p' ‐DDT‐induced increases of aspartate in the brainstem and spinal cord, 5‐HIAA in the hippocampus, and MHPG in the brainstem and hypothalamus. Phenytoin significantly enhanced chlordecone‐induced increases of MHPG in the brainstem. These data indicate that organo‐chlorine‐induced increases in noradrenergic activity in the brainstem and spinal cord may be directly related to the tremorigenic effects of these chemicals.