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Stimulatory Effects of Growth Hormone and Thyroxine on the Concentration of Gangliosides in the Snell Dwarf Cerebrum
Author(s) -
Noguchi Tetsuya,
Sugisaki Tetsuro
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb13089.x
Subject(s) - cerebrum , ganglioside , endocrinology , medicine , biology , hormone , central nervous system , biochemistry
The concentration of gangliosides in the Snell dwarf mouse cerebrum was monitored from postnatal day 5 to day 40. In the dwarf cerebrum, the concentration of total gangliosides increased up to postnatal day 20 and then stopped, whereas in the control cerebrum, it continued to increase up to postnatal day 40. At postnatal day 40, the ganglioside level in the dwarf cerebrum was 70% of that in the control cerebrum. Among the ganglioside species, the concentrations of G M4 , G M2 , G M1 , G D1a , G D3 , G D1b , G T1b , and G Q1b were significantly lower in the dwarf cerebrum than in the controls at postnatal day 40. The reduced concentrations of ganglioside species G M2 , G D1a , G D3 , G D1b , and G Q1b , were completely restored by administration of bovine growth hormone (GH) during the first 20 days of postnatal life. The reduced concentration of the G M1 and G M4 species were most efficiently restored by administration of bovine GH plus thyroxine (T 4 ) during the second 20 days of postnatal life. These results indicate that the lower ganglioside concentrations in the dwarf cerebrum can be elevated by hormone therapy and that there exist distinct GH and T 4 actions on the enzymes participating in ganglioside metabolism.