Premium
Binding of the Novel Serotonin Agonist 8‐Hydroxy‐2‐(Di‐ n ‐Propylamino) Tetralin in Normal and Alzheimer Brain
Author(s) -
Middlemiss D. N.,
Palmer A. M.,
Edel N.,
Bowen D. M.
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb13069.x
Subject(s) - neocortex , serotonin , temporal cortex , agonist , cortex (anatomy) , human brain , medicine , endocrinology , neuroscience , binding site , cerebral cortex , chemistry , receptor , 5 ht receptor , central nervous system , biology , biochemistry
Binding of [ 3 H]8‐hydroxy‐2‐(di‐ n ‐propylamino) tetralin. a putative ligand for the 5‐hydroxytryptamine (5‐ HT, serotonin) 1A recognition site, was measured in neocortex from postmortem human brain. The substance was found to bind to a saturable site with a K D value and pharmacological profile similar to that of rat. Binding to membranes from normal human temporal cortex was found to significantly correlate (inversely) with age. A significant reduction in binding, reflecting decreased density of recognition sites, was observed in the frontal cortex of patients with Alzheimer's disease (48% loss). This region in the dement brains showed unaltered presynaptic 5‐HT function (5‐HT and 5‐hydroxyindoleacetic acid content) whereas 5‐HT concentration was reduced in the temporal cortex.