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Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia
Author(s) -
Shimohama Shun,
Taniguchi Takashi,
Fujiwara Motohatsu,
Kameyama Masakuni
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb12960.x
Subject(s) - nucleus basalis , muscarinic acetylcholine receptor , nicotinic agonist , quinuclidinyl benzilate , cholinergic , endocrinology , medicine , muscarinic acetylcholine receptor m4 , acetylcholine receptor , neuroscience , nicotine , receptor , chemistry , biology , cholinergic neuron
Abstract: Nicotinic and muscarinic cholinergic receptors were studied in autopsied brains from four histologically normal controls and five histopathologically verified cases of Alzheimer‐type dementia (ATD), using ligand binding techniques. Nicotinic and muscarinic cholinergic receptors were assessed by (–)‐[ 3 H]nicotine and [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB), respectively. Compared with the controls, (–)‐[ 3 H]nicotine binding sites in the ATD brain regions examined were significantly reduced in the putamen and the nucleus basalis of Meynert (NbM). [ 3 H]QNB binding was significantly reduced in the hippocampus and NbM. These findings suggest that there are significant changes of nicotinic and muscarinic cholinergic receptors in selected regions of ATD brains.