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Recovery of Altered Fatty Acid Composition Induced by a Diet Devoid of n‐3 Fatty Acids in Myelin, Synaptosomes, Mitochondria, and Microsomes of Developing Rat Brain
Author(s) -
Youyou A.,
Durand G.,
Pascal G.,
Piciotti M.,
Dumont O.,
Bourre J. M.
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb12950.x
Subject(s) - docosapentaenoic acid , sunflower oil , docosahexaenoic acid , arachidonic acid , food science , biology , polyunsaturated fatty acid , fatty acid , composition (language) , sunflower , biochemistry , litter , sunflower seed , corn oil , zoology , chemistry , agronomy , enzyme , linguistics , philosophy
Rats were fed a semisynthetic diet containing either sunflower oil or soya oil. Half the litter fed with sunflower oil diet was changed to a soya oil diet when the pups were 15 days old (during active myelination). Fatty acid analysis was then performed on subcellular fractions of the animals fed (a) soya oil, (b) sunflower oil, and (c) soya oil replacing sunflower oil from the 15th day, to determine the speed of the recovery. All material from animals fed sunflower oil showed an important reduction in docosahexaenoic acid (22:6 n‐3), compensated by an increase in docosapentaenoic acid (22:5 n‐6), whereas arachidonic acid (20:4 n‐6) was not affected. In all fractions examined, when sunflower oil was replaced by soya oil in 15‐day‐old pups the recovery started from the very first day but lasted more than 2 months (this recovery was determined by the increase of 22:6 n‐3 up to the normal value and decrease of the 22:5 n‐6). In addition a delay was found for myelin recovery, starting only from the 25th day.