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Local Cerebral Glucose Utilisation Following Indoleamine‐ and Piperazine‐Containing 5‐Hydroxytryptamine Agonists
Author(s) -
Grome John J.,
Harper A. Murray
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb12933.x
Subject(s) - piperazine , chemistry , serotonin , pharmacology , deoxyglucose , endocrinology , medicine , biochemistry , receptor
Substances with varying structural components have been shown to have 5‐hydroxytryptamine (5‐HT)‐like properties in the CNS. In this study, putative 5‐HT agonists with indoleamine moeities—lysergic acid diethylamide (LSD) and 5‐methoxy‐ N,N ‐dimethyltryptamine (5‐MeODMT)—and with piperazine moeities—quipazine (Quip) and 6‐chloro‐2‐(1‐piperazinyl)pyrazine (6‐CPP) were administered to rats. Local cerebral glucose utilisation was measured using the [ 14 C]2‐deoxyglucose autoradiographic technique. It was found that in most cerebral structures, these substances produced dose‐dependent reductions in glucose utilisation. However, Quip and 6‐CPP increased glucose utilisation in specific areas of the diencephalon (e.g., nucleus reuniens) and produced a biphasic effect in some but not all extrapyramidal structures (e.g., ventromedial caudate nucleus). No such increases in local cerebral glucose utilisation were measured following LSD or 5‐MeODMT administration. These results indicate that although similarities exist between the effects of indoleamine‐ and piperazine‐containing 5‐HT agonists on local cerebral glucose utilisation there are also significant differences in the overall patterns of response produced.