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Spontaneous Release of γ‐Aminobutyric Acid Formed from Putrescine and Its Enhanced Ca 2+ ‐Dependent Release by High K + Stimulation in the Brains of Freely Moving Rats
Author(s) -
Noto Tadashi,
Hashimoto Hiromichi,
Nakao Junji,
Kamimura Hiroshi,
Nakajima Teruo
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb08507.x
Subject(s) - putrescine , stimulation , putamen , aminobutyric acid , caudate nucleus , liberation , chemistry , perfusion , biophysics , medicine , endocrinology , biochemistry , biology , in vitro , enzyme , receptor
The spontaneous release of [ 3 H]γ‐aminobutyric acid ([ 3 H]GABA) in various areas of rat brain in jected with [ 3 H]putrescine was examined using a push pull perfusion technique. The release in a 25‐min perfusate was highest in the caudate‐putamen. The effect of high K + stimulation on the release of [ 3 H]GABA formed from [ 3 H]putrescine was examined in the caudate‐putamen. The release was enhanced by high K + solution in a Ca 2+ ‐dependent manner.