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Electroconvulsive Shock and Cyclic AMP Signal Transduction: Effects Distal to the Receptor
Author(s) -
Newman Michael E.,
Solomon Haim,
Lerer Bernard
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb08482.x
Subject(s) - adenylate kinase , forskolin , cyclase , guanosine , medicine , endocrinology , stimulation , chemistry , electroconvulsive shock , receptor , signal transduction , membrane , biophysics , biology , biochemistry
Chronic electroconvulsive shock (ECS) induced a significant decrease in noradrenaline‐ and forskolin‐stimulated cyclic AMP production in rat cortical slices, whereas a single ECS had a much smaller effect. In a cortical membrane preparation, adenylate cyclase activity in response to stimulation by forskolin, guanosine‐5′‐(β,γ‐imido)triphosphate, and Mn 2+ ions was significantly increased in membranes derived from rats that had received chronic ECS, but was either unchanged or reduced in membranes from rats that received a single treatment only. The results are interpreted in terms of changes occurring at components of the adenylate cyclase enzyme distal to the receptor.