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Chromogranin C: A Third Component of the Acidic Proteins in Chromaffin Granules
Author(s) -
FischerColbrie Reiner,
Hagn Claus,
Kilpatrick Lynn,
Winkler Hans
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb02865.x
Subject(s) - chromogranin a , chemistry , component (thermodynamics) , chromaffin cell , endocrinology , medicine , biochemistry , adrenal medulla , biology , catecholamine , immunohistochemistry , physics , thermodynamics
We characterized a group of acidic proteins of bovine chromaffin granules with an antiserum raised against a protein described by Rosa and Zanini [ Eur. J. Cell Biol . 31, 94–98 (1983)] in pituitary gland. In adrenal medulla the proteins reacting with this antiserum are confined to chromaffin granules. Their largest component has a M r of 86,000 and a pl of 5.0. In addition six proteins of lower molecular weight are recognized by this antiserum. In a cell‐free system only one protein is synthesized that can be precipitated with this antiserum. The properties of these proteins are very similar to those of the previously described chromogranins A and B; however, there is no immunological cross‐reaction between these protein groups. We suggest this third group of acidic proteins of chromaffin granules be named chromogranins C.