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Atrial Natriuretic Hormones Raise the Level of Cyclic GMP in Neural Cell Lines
Author(s) -
Friedl Arno,
Harmening Christine,
Hamprecht Bernd
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb01771.x
Subject(s) - hormone , extracellular , atrial natriuretic peptide , intracellular , medicine , peptide hormone , endocrinology , npr2 , npr1 , cyclic gmp , chemistry , peptide , biological activity , natriuretic peptide , biology , biochemistry , in vitro , heart failure , nitric oxide
Atriopeptin III and related atrial natriuretic peptide hormones strongly elevate the level of cyclic GMP in three neural tumor cell lines. At peptide concentrations of 1 γ M clear‐cut plateaus of the dose‐response curves are not yet reached. Atriopeptin III increases the intracellular concentration of cyclic GMP to a maximum in the course of 30–40 min. The effect of atriopeptin III on the cellular cyclic GMP level is independent of the concentration of extracellular Ca 2+ and is not affected by the Ca 2+ ionophore A23187. These results suggest (1) that atrial natriuretic hormones may play an important role in the nervous system, and (2) that cultured neural cells may be useful tools in the elucidation of the mechanisms of action of these hormones.