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Taurine Levels in Discrete Brain Nuclei of Rats
Author(s) -
Palkovits Miklós,
Elekes István,
Láng Tibor,
Patthy András
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb00761.x
Subject(s) - taurine , endocrinology , medicine , hypothalamus , caudate nucleus , chemistry , locus coeruleus , cerebellum , midbrain , brainstem , midbrain reticular formation , substantia nigra , cerebral cortex , reticular formation , dopamine , biology , central nervous system , biochemistry , amino acid , dopaminergic
Concentrations of taurine have been measured in 44 microdissected rat brain nuclei or areas. Taurine is ubiquitously present and distributed unevenly in the rat brain: the ratio of the highest (pyriform cortex) to lowest (midbrain reticular formation) concentrations is 4.7:1. High taurine levels were found in cerebral cortical areas, caudate‐puta‐men, cerebellum, median eminence, and supraoptic nucleus. Acute pain stress reduced taurine levels in the hypothalamus and the lower brainstem nuclei but not in cortical areas. Increased locomotor and behavioral activities following a high dose of amphetamine elevated taurine concentrations significantly in the substantia nigra and locus ceruleus.