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Expression of Synaptophysin During Postnatal Development of the Mouse Brain
Author(s) -
Knaus Petra,
Betz Heinrich,
Rehm Hubert
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb00754.x
Subject(s) - synaptophysin , synaptogenesis , synaptic vesicle , cerebrum , biology , microbiology and biotechnology , neuroscience , endocrinology , immunohistochemistry , vesicle , central nervous system , immunology , membrane , biochemistry
The expression of the synaptic vesicle membrane protein, synaptophysin, was analyzed during postnatal development of the mouse cerebrum using a quantitative immunoblotting procedure. From birth to adulthood, the relative contents of synaptophysin increased 80‐fold, reaching a final level of 3.5 μg/mg of total protein. The time course of accumulation suggests that synaptophysin expression is correlated with synaptogenesis. Thus synaptophysin may be used as a reliable marker of nerve terminal differentiation.