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Differences in Anionic Dependence of the Synaptic Efflux of d‐Aspartic Acid and γ‐Aminobutyric Acid
Author(s) -
Naalsund Liv Unni,
Fonnum Frode
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb00666.x
Subject(s) - efflux , incubation , propionate , chemistry , aspartic acid , hippocampal formation , aminooxyacetic acid , aminobutyric acid , biochemistry , endocrinology , biology , amino acid , enzyme , receptor
The synaptosomal effluxes of d‐aspartate and γ‐aminobutyric acid (GABA) induced by a substitution of the Cl‐ ions with propionate in the incubation medium were measured in preparations of hippocampal tissue homogenates. The efflux of aspartate was significantly higher than spontaneous efflux at 125 m M Cl‐ (normal = 144 m M ) and was increased with decreasing Cl‐ concentration. GABA efflux was much less sensitive to a reduction in Cl concentration than D‐aspartate. The efflux was Ca 2+ ‐dependent in both cases.