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Low Levels of γ‐Aminobutyric Acid in Cerebrospinal Fluid of Dogs with Epilepsy
Author(s) -
Löscher Wolfgang,
SchwartzPorsche Dorothea
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb00658.x
Subject(s) - cerebrospinal fluid , epilepsy , aminobutyric acid , primidone , medicine , endocrinology , tonic (physiology) , gamma aminobutyric acid , petit mal , chemistry , anticonvulsant , biology , neuroscience , receptor
γ‐Aminobutyric acid (GABA) levels were determined in cisternal cerebrospinal fluid (CSF) of 19 epileptic dogs with generalized tonic‐clonic (grand mal) seizures using a radioreceptor assay. Thirty‐four healthy age‐matched dogs served as controls. The average CSF GABA level in epileptic dogs (40 pmol/ml) was significantly lower than that determined in controls (66 pmol/ml). Treatment with phenobarital or primidone seemed not to affect CSF GABA levels.