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Motor Activity Increases Tryptophan, 5‐Hydroxyindoleacetic Acid, and Homovanillic Acid in Ventricular Cerebrospinal Fluid of the Conscious Rat
Author(s) -
Chaouloff F.,
Laude D.,
Guezennec Y.,
Elghozi J. L.
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb00656.x
Subject(s) - homovanillic acid , serotonergic , 5 hydroxyindoleacetic acid , medicine , dopaminergic , endocrinology , cerebrospinal fluid , metabolite , dopamine , serotonin , chemistry , receptor
An investigation was made into the effects of running (I h at 20 m/min) on central serotonergic and dopaminergic metabolism in trained rats. Methodology involved continuous withdrawal of cerebrospinal fluid (CSF) from the third ventricle of conscious rats and measurements of tryptophan (TRP), 5‐hydroxyindoleacetic acid (5‐HIAA), and homovanillic acid (HVA) levels during a 2 h post‐exercise period. All three compounds were increased during the hour following exercise and returned to their basal values within an hour later. CSF flow rate was stable when metabolite levels were elevated. Brain determinations indicated that CSF metabolite variations only qualitatively paralleled brain changes. Indeed, post‐exercise TRP, 5‐HIAA, and HVA levels were increased to a greater extent in brain when compared to CSF. It is suggested that increased serotonergic and dopaminergic metabolism, caused by motor activity, may be involved in the behavioral effects of exercise.