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Isolation and Identification of α‐(γ‐Aminobutyryl)‐Hypusine
Author(s) -
Sano Akira,
Kotani Kazuhiko,
Kakimoto Yasuo
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb00616.x
Subject(s) - dipeptide , trichloroacetic acid , isolation (microbiology) , chemistry , biochemistry , chromatography , biology , amino acid , bioinformatics
A new dipeptide, α‐(‐γ‐aminobutyryl)‐hypusine, was identified in bovine brain. This compound was isolated from trichloroacetic acid‐soluble fraction of bovine brain with five steps of ion‐exchange chromatography. Its structure was postulated by routine chemical analyses and determined by synthesis. The amount of the compound isolated from 1.2 kg of bovine brain was 870 nmol.