Premium
Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress
Author(s) -
Martins Ralph N.,
Harper Clive G.,
Stokes Gilbert B.,
Masters Colin L.
Publication year - 1986
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1986.tb00615.x
Subject(s) - oxidative stress , alzheimer's disease , dehydrogenase , disease , glucose 6 phosphate dehydrogenase , endocrinology , neuroscience , medicine , chemistry , biochemistry , biology , enzyme
The activities of the hexose monophosphate pathway enzymes glucose‐6‐phosphate dehydrogenase and 6‐phosphogluconate dehydrogenase were measured at autopsy in control and Alzheimer's disease brains. Enzyme activities did not vary between different areas of brain and were unaltered by age. In Alzheimer's disease, the activities of both enzymes were increased, the glucose‐6‐phosphate dehydrogenase activity being almost double the activity of normal controls. We propose that this increased enzyme activity is a response to elevated brain peroxide metabolism.