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Evidence for the Presence of a Ganglioside Transfer Protein in Brain
Author(s) -
Gammon CM.,
Ledeen R. W.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb12912.x
Subject(s) - ganglioside , myelin , white matter , vesicle , chemistry , biochemistry , sonication , biophysics , chromatography , membrane , biology , central nervous system , neuroscience , medicine , radiology , magnetic resonance imaging
An extract from rat brain has been shown to catalyze the transfer of ganglioside G M1 from sonicated vesicles to erythrocyte ghosts. It also enhanced the transfer of G M1 to a crude neuronal membrane preparation, whereas myelin took up only a very limited amount. The transfer activity was heat‐labile. Similar transfer activities were found in extracts from bovine gray and white matter, that of the former being comparable to rat brain whereas the latter was greater per milligram protein.