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Effect of the Cerebral Tryptaminergic System on the Turnover of Dopamine in the Striatum of the Rat
Author(s) -
Fuenmayor L. D.,
Bermúdez M.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb12866.x
Subject(s) - homovanillic acid , dopamine , chemistry , endocrinology , medicine , methysergide , striatum , nigrostriatal pathway , dopaminergic , 3,4 dihydroxyphenylacetic acid , dopamine receptor , serotonin , receptor , biochemistry , substantia nigra
The effect of the cerebral 5‐hydroxytryptamine system on the turnover of striatal 3,4‐dihydroxyphenyl‐ethylamine (dopamine) was investigated by measuring the level of dopamine and one of its metabolites in rats depleted of cerebral 5‐hydroxytryptamine or treated with a 5‐hydroxytryptamine receptor blocker. Treatment with p ‐chlorophenylalanine induced, in addition to a reduction in striatal 5‐hydroxytryptamine and 5‐hydroxyindol‐3‐ylacetic acid, an increase in the striatal concentration of dopamine, a diminution in the concentration of homovanillic acid in the same cerebral area, and a reduction in the rise of this acid after the administration of a butyrophenone derivative or tetrabenazine. Treatment with methysergide also reduced the increase of homovanillic acid induced by the butyrophenone. When probenecid was given to rats treated with p ‐chlorophenylalanine, homovanillic acid failed to accutnulate, whereas the accumulation of 5‐hydroxyindol‐3‐ylacetic acid was unaffected. The decay of dopamine after α‐methyl‐ p ‐tyrosine administration was normal for the first 6 h but was later reduced in rats given p ‐chlorophenylalanine or methy‐sergide. The results suggest that the lack of activation of 5‐hydroxytryptamine receptors leads to a reduction in the turnover of dopamine in the nigrostriatal pathway.