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N‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Increases Acetylcholine and Decreases Dopamine in Mouse Striatum: Both Responses Are Blocked by Anticholinergic Drugs
Author(s) -
Hadjiconstantinou M.,
Cavalla D.,
Anthoupoulou E.,
Laird H. E.,
Neff N. H.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb10558.x
Subject(s) - mptp , dopamine , neurotoxin , parkinsonism , acetylcholine , trihexyphenidyl , atropine , striatum , chemistry , pharmacology , anticholinergic , benztropine , medicine , endocrinology , neuroscience , biology , dopaminergic , disease
The neurotoxin N ‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) produces neuropathology and clinical symptoms that resemble Parkinsonism in primates and humans. In mice it induces a long‐lasting depletion of neostriatal 3,4‐dihydroxyphenylethylamine (dopamine) content. Using the mouse, we found that MPTP induces a fall of dopamine and a rise of acetylcholine in the neostriatum. Both responses to MPTP can be blocked by prior treatment with atropine or trihexyphenidyl.