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Regulation of Anterior Pituitary D 2 Dopamine Receptors by Magnesium and Sodium Ions
Author(s) -
Watanabe Masayuki,
George Susan R.,
Seeman Philip
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb10542.x
Subject(s) - anterior pituitary , magnesium , sodium , dopamine , endocrinology , receptor , medicine , chemistry , calcium , dopamine receptor , biochemistry , biology , hormone , organic chemistry
At D 2 3,4‐dihydroxyphenylethylamine (dopamine) receptors in anterior pituitary tissue, magnesium ions shifted receptors to agonist high‐affinity states, but decreased the affinity of the antagonist [ 3 H]spiperone. Conversely, sodium ions shifted the receptors to agonist low‐affinity states, but increased the affinity of [ 3 H]spiperone. Magnesium is proposed to stabilize the hormone–receptor–guanine nucleotide regulatory protein complex, whereas sodium appears to destabilize this ternary complex. Thus, magnesium and sodium appear to mediate their regulatory effects via a common component at the D 2 dopamine‐receptor ternary complex.