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Low Activity of Angiotensin‐Converting Enzyme in Cerebral Microvessels of Young Spontaneously Hypertensive Rats
Author(s) -
Kobayashi Hideyuki,
Wada Akihiko,
Izumi Futoshi,
Take Keiko,
Magi Maria Sandra
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb08761.x
Subject(s) - medicine , microcirculation , endocrinology , pathogenesis , spontaneously hypertensive rat , cerebral circulation , angiotensin converting enzyme , animal model , cerebral cortex , enzyme , renin–angiotensin system , chemistry , blood pressure , biochemistry
Angiotensin‐converting enzyme (ACE) activity was measured in microvessels prepared from cerebral cortices of 4‐week‐old spontaneously hypertensive rats (SHR). The V max value of the ACE activity in the cerebral microvessels of SHR was lower than that of Wistar Kyoto controls of the same age by 25% without difference in K m value for substrate. The low activity of ACE in the cerebral microvessels of young SHR indicates that in this animal model of hypertension the function of ACE is genetically altered in the cerebral microvessels, which may be correlated with the alteration of the cerebral microcirculation and pathogenesis of hypertension.