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Effect of Intraventricular Putrescine on Adenosylmethionine Decarboxylase in Rat Hypothalamus and Caudate Nucleus
Author(s) -
Ientile Riccardo,
Ruggeri Pietro,
Russo Pietro,
Macaione Salvatore
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb08760.x
Subject(s) - putrescine , caudate nucleus , hypothalamus , medicine , endocrinology , ornithine decarboxylase , chemistry , in vivo , glutamate decarboxylase , enzyme , biology , biochemistry , microbiology and biotechnology
Effects of intracerebroventricularly injected putrescine on adenosylmethionine decarboxylase activity in rat hypothalamus and caudate nucleus were studied. Doses that lacked the capacity to produce behavioral and electrocortical epileptogenic disorder caused a significant activation of enzyme occurring between 10 and 15 min after injection. The changes in hypothalamic and caudate nucleus enzyme activity after putrescine administration were dose‐dependent, and they supported the assumption that limiting putrescine concentration in vivo may play a role in adenosylmethionine decarboxylase regulation.