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Effects of Repeated Administration of Estradiol Benzoate on Tubero‐Infundibular GABAergic Activity in Male Rats
Author(s) -
Nicoletti Ferdinando,
Grandison Lindsey,
Meek James L.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb08746.x
Subject(s) - median eminence , medicine , endocrinology , glutamate decarboxylase , estradiol benzoate , gabaergic , arcuate nucleus , substantia nigra , caudate nucleus , chemistry , glutamate receptor , hypothalamus , nucleus , dopamine , biology , estrogen , enzyme , neuroscience , ovariectomized rat , biochemistry , receptor , inhibitory postsynaptic potential , dopaminergic
Abstract: Repeated (once a day for 8 days) but not single administration of estradiol benzoate (10 μg/kg, s.c.) induced a sevenfold increase in anterior pituitary γ‐aminobutyric acid (GABA) concentration in male rats. GABA concentration also increased in the median eminence whereas no changes or decreases were observed in other brain regions including hypothalamic arcuate nucleus, lateral septum, hippocampus, caudate nucleus, and substantia nigra. Eight‐day estradiol benzoate injection also enhanced the V max of median eminence glutamate decarboxylase activity without affecting the K m of the enzyme for glutamic acid. Taken together, these results suggest that repeated administration of estradiol benzoate increases the activity of the tubero‐infundibular GABAergic system in male rats.