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Restricted Transport of Vitamin D and A Derivatives Through the Rat Blood‐Brain Barrier
Author(s) -
Pardridge William M.,
Sakiyama Roland,
Coty William A.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb08735.x
Subject(s) - blood–brain barrier , retinoic acid , albumin , vitamin , chemistry , medicine , endocrinology , serum albumin , biochemistry , retinol , biology , central nervous system , gene
The present studies measure the transport of retinol, retinoic acid, 1,25‐dihydroxyvitamin D 3 [1,25‐(OH) 2 D 3 ], and 25‐hydroxyvitamin D 3 [25‐(OH)D 3 ] through the rat brain capillary endothelial wall, i.e., the blood‐brain barrier (BBB). The vitamin A and D derivatives bind both to albumin and to specific high‐affinity binding proteins in plasma. In the presence of physiologic concentrations of plasma proteins, the extraction by brain of all four compounds was 5% or less.