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Cerebellum Lipids in Rats After Chronic Ethanol Treatment
Author(s) -
Vrbaški SneŽana R.,
Ristić Milosav
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb07181.x
Subject(s) - phosphatidylserine , phosphatidylethanolamine , phosphatidylcholine , phosphatidylinositol , ganglioside , ethanol , phospholipid , cerebellum , chemistry , biochemistry , glycolipid , sucrose , myelin , medicine , alcohol , endocrinology , food science , biology , central nervous system , membrane , kinase
Eighteen male Wistar rats weighing approximately 200 g were divided into three groups of six animals each. The experimental animals were maintained on nutritionally complete diets in which ethanol comprised 45% of the available energy. Control animals were pair‐fed an equivalent diet in which sucrose was substituted isocalorically for ethanol. An additional control group received unlimited access to standard pelleted laboratory food and water. The investigations were carried out over 24 weeks. The effects on phospholipid, monogalactosyl glycolipid, and ganglioside composition after 24 weeks of feeding 43% alcohol were studied. There is abundant evidence that the changes in the cerebellum membrane phospholipids (phosphatidylethanolamine and phosphatidylcholine), gangliosides (G Tlb ), and myelin lipids (phosphatidylserine, sphingophospholipid, phosphatidylinositol, cerebrosides with hydroxy fatty acids, sulfoglycolipids, and monosialoganglioside G M1 ) occur as a result of chronic ethanol treatment.