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Short Communication Occupation of Dopamine Receptors by N ‐ n ‐Propylnorapomorphine or Spiperone and Acetylcholine Levels in the Rat Striatum
Author(s) -
Korf Jakob,
Sebens Jantiena B.,
Flentge Frans,
Werf Jan F.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb07147.x
Subject(s) - spiperone , acetylcholine , endocrinology , medicine , chemistry , dopaminergic , dopamine receptor , striatum , muscarinic acetylcholine receptor , agonist , dopamine , muscarinic acetylcholine receptor m4 , cholinergic , receptor , biology , biochemistry
In an attempt to quantify the interactions between dopaminergic and cholinergic processes, the consequences of complete or partial activation (with N ‐ n ‐propylnorapomorphine) or blockade (with spiperone) of dopamine receptors for the acetylcholine levels in the rat striatum were studied. The number of specific striatal binding sites (receptors) of spiperone was nearly three times that of N ‐ n ‐propylnorapomorphine (76 and 26 pmol g −1 wet weight, respectively). The agonist produced a significant increase in the striatal levels of acetylcholine, but there was no simple relationship between receptor binding and these levels. A linear negative correlation was found between the striatal levels of acetylcholine and specific spiperone binding, showing that further receptor blockade induces a decrease in acetylcholine levels, which is independent of the receptors already occupied by the antagonist. The results of this study are evidence that one striatal dopamine receptor regulates the metabolism of at least 400 molecules of acetylcholine.