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Chromatin Proteins Share Antigenic Determinants with Neurofilaments
Author(s) -
Wood John N.,
Lathangue Nicholas B.,
McLachlan Donald R.,
Smith Bryan J.,
Anderton Brian H.,
Dowding Alan J.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb07124.x
Subject(s) - neurofilament , monoclonal antibody , histone , chromatin , epitope , antigen , antibody , senile plaques , alzheimer's disease , biology , non histone protein , chemistry , disease , immunology , biochemistry , immunohistochemistry , medicine , pathology , gene
Antigenic determinants common to distinct proteins may be unambiguously identified by the use of monoclonal antibodies. Some monoclonal antibodies to mammalian neurofilaments have recently been shown to cross‐react with the neurofibrillary tangles found at high density in the brains of senile dements with Alzheimers disease (SDAT). Here, we show that these antibodies also cross‐react with chromatin proteins, including the linker histones H 1 and H 1 0 . Elevated levels of histone H 1 0 have also been reported in SDAT brains.