Premium
Retrograde Effect of Muscle on Forms of Acetylcholinesterase in Peripheral Nerves
Author(s) -
Bacou F.,
Vigneron P.,
Couraud J. Y.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb05539.x
Subject(s) - acetylcholinesterase , axoplasmic transport , aché , anatomy , peripheral , chemistry , biology , neuroscience , enzyme , medicine , biochemistry
In the peripheral nerves of birds and mammals, acetylcholinesterase (AChE) exists in four main molecular forms (G 1 , G 2 , G 4 , and A 12 ). The two heaviest forms (G 4 and A 12 ) are carried by rapid axoplasmic transport, whereas the two lightest forms (G 1 and G 2 ) are probably much more slowly transported. Here we report that nerves innervating fast‐twitch (F nerves) and slow‐twitch (S nerves) muscles of the rabbit differ both in their AChE molecular form patterns and in their anterograde and retrograde axonal transport parameters. Since we had previously shown a selective regulation of this enzyme in fast and slow parts of rabbit semimembranosus muscle, we wondered whether the differences observed in the nerve could be affected by the twitch properties of muscle. The results reported here show that in F nerves that reinnervate slow‐twitch muscles, both the AChE molecular form patterns and axonal transport parameters turn into those of the S nerve. These data suggest the existence of a retrograde specific effect exerted by the muscles on their respective motoneurons.