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Age‐Dependent Changes in Brain GABA Turnover Rates in Two Inbred Strains of Mice
Author(s) -
Ciesielski L.,
Simler S.,
Clement J.,
Mandel P.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb05500.x
Subject(s) - medicine , endocrinology , gabaergic , inbred strain , turnover , gamma aminobutyric acid , biology , neurotransmission , steady state (chemistry) , superior colliculus , ratón , chemistry , neuroscience , receptor , biochemistry , gene , inhibitory postsynaptic potential , management , economics
γ‐Aminobutyric acid (GABA) steady‐state levels and turnover rates have been determined in 15 brain areas of 21‐day‐ and 3‐month‐old DBA/2J (DBA) and C57B1/6J (C57) mice. These two inbred strains differ by their susceptiblity to audiogenic seizures; moreover, the involvement of GABAergic neurotransmission has been suggested in the control of this behavior. Turnover rates are generally higher at 21 days than at 3 months of age. There are few significant differences in the GABA steady‐state levels between 21‐day‐old seizure‐prone DBA mice when compared with seizure‐resistant C57 mice. In the DBA mice, the steady‐state level is higher in the olfactory bulbs and lower in the posterior colliculus and the olfactory tubercles than in the C57 mice. Although there are some significant differences in GABA turnover rates and steady‐state levels, intra or inter strains, it is difficult to correlate directly these differences with seizure susceptibility.