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Dopamine Uptake is Differentially Regulated in Rat Striatum and Nucleus Accumbens
Author(s) -
Missale Cristina,
Castelletti Laura,
Govoni Stefano,
Spano Pier Franco,
Trabucchi Marco,
Hanbauer Ingeborg
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb05473.x
Subject(s) - nucleus accumbens , striatum , dopamine , neuroscience , basal ganglia , ventral striatum , nucleus , chemistry , psychology , central nervous system
Active uptake of 3,4‐dihydroxyphenylethylamine (dopamine) is sodium‐ and temperature‐dependent, strongly inhibited by benztropine and nomifensine, and present in corpus striatum and nucleus accumbens. In rat striatum dopamine uptake is related to a receptor that is specifically labelled by [ 3 H]cocaine in the presence of Na + and is located on dopaminergic terminals. The dopamine uptake is differentially affected in the two areas by single or repeated injections of cocaine. Cocaine inhibits dopamine uptake in slices of corpus striatum. Moreover Na + ‐dependent [ 3 H]cocaine binding is not detectable in nucleus accumbens. Nomifensine inhibits [ 3 H]dopamine uptake by interacting with low‐ and high‐affinity sites in corpus striatum, but shows only low affinity for dopamine uptake in nucleus accumbens. The present data indicate that different mechanisms are involved in the regulation of dopamine uptake in corpus striatum and nucleus accumbens.