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True Renin in Human Pituitary Tissue
Author(s) -
Mizuno Kenji,
Ojima Motoko,
Gotoh Mitsuhiro,
Hashimoto Shigeatsu,
Fukuchi Soitsu
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb05459.x
Subject(s) - renin–angiotensin system , proteases , kidney , trypsin , endocrinology , pituitary gland , chemistry , medicine , anterior pituitary , human kidney , biology , biochemistry , enzyme , hormone , blood pressure
Readily detectable levels of renin activity were demonstrated in human pituitary tissues. This activity was inhibited by specific antibody raised against human renal renin, indicating that it was not due to the nonspecific action of proteases. It shared some biochemical features with well‐known kidney renin, such as molecular weight, optimum pH, and the presence of trypsin‐activatable inactive renin. These results suggest that true renin exists in human pituitary tissue.