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Comparison of the Vascular Permeability of the Brain and the Spinal Cord to Mannitol and Inulin in Rats
Author(s) -
Daniel P. M.,
Lam D. K. C.,
Pratt O. E.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb04038.x
Subject(s) - mannitol , inulin , spinal cord , vascular permeability , permeability (electromagnetism) , chemistry , anatomy , medicine , neuroscience , biology , biochemistry , membrane
The kinetics of the movement of [14C]mannitol and [14C]inulin from the blood into the CNS of the rat were measured. The spinal cord was found to have a higher permeability to these two substances than the brain. It is likely that the channels through which the tracers diffused are larger in the capillaries of the spinal cord than those in the brain.