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Effects of Hypoglycemia on Rat Brain Polyribosome Sedimentation Pattern
Author(s) -
Ulovec Z.,
Narancsik P.,
Gamulin S.
Publication year - 1985
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1985.tb03995.x
Subject(s) - hypoglycemia , polysome , endocrinology , medicine , cycloheximide , tolbutamide , insulin , ribosome , chemistry , biology , protein biosynthesis , biochemistry , rna , gene
Insulin‐induced hypoglycemia provokes polyribosome disaggregation and accumulation of monomeric ribosomes in the brain of rats with hypoglycemic paresis and coma. The extent of brain polyribosome disaggregation depends on the decrease of blood glucose concentration, and in comatose animals on the duration of hypoglycemia. Cycloheximide prevents the disaggregation of brain polyribosomes induced by hypoglycemia, indicating that hypoglycemia affects brain protein synthesis, decreasing the rate of initiation relative to the rate of elongation of polypeptide chain synthesis.