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Opiates Stimulate Low K m GTPase in Brain
Author(s) -
Franklin Paul H.,
Hoss Wayne
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb12853.x
Subject(s) - gtpase , (+) naloxone , opiate , stimulation , opioid , chemistry , gtp' , etorphine , opioid peptide , antagonist , medicine , endocrinology , pharmacology , neuroscience , receptor , biochemistry , biology , enzyme
Abstract: Low K m GTP hydrolysis in rat brain is stimulated in a concentration‐dependent manner by the opiate alkaloid etorphine, and by the opioid peptide d ‐Ala 2 ‐leucine‐enkephalinamide. The opiate antagonist naloxone inhibits the maximal d ‐Ala 2 ‐leucine‐enkephalinamide stimulation of the GTPase, also with concentration dependency. The magnitude of maximally stimulated, opioid‐sensitive, GTP hydrolysis is differentially distributed across brain regions. Opioid‐stimulated GTPase may represent one means of identifying a specific type of opioid receptor.