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Colchicine Neurotoxicity Demonstrates the Cholinergic Projection from the Supracommissural Septum to the Habenula and the Nucleus Interpeduncularis in the Rat
Author(s) -
Fonnum Frode,
Contestabile Antonio
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb12814.x
Subject(s) - colchicine , habenula , cholinergic , choline acetyltransferase , fornix , nucleus , hippocampal formation , interpeduncular nucleus , hippocampus , anatomy , neuroscience , biology , chemistry , medicine , endocrinology , central nervous system , midbrain
Colchicine injections in the supracommissural septum of the rat caused degeneration of several neurons in the nucleus triangularis septi and the nucleus septo‐fimbrialis. The lesions resulted in significant decreases of choline acetyltransferase in the habenula (–34%) and in the nucleus interpeduncularis (–36%), thus demonstrating the existence of a major cholinergic projection to these nuclei from the supracommissural septum. A large fall in choline acetyltransferase was also noticed in the dorsal hippocampus as a consequence of colchicine damage to the fimbria‐fornix fibers crossing the injected area.