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Determination of 1‐Methylimidazole‐4‐Acetic Acid in Brain Tissue from Rat and Mouse
Author(s) -
Swahn CarlGunnar
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb12805.x
Subject(s) - acetic acid , cerebrum , cerebellum , metabolite , histamine , brain tissue , chemistry , biochemistry , chromatography , endocrinology , medicine , biology , central nervous system
The concentration of the histamine metabolite 1‐methylimidazole‐4‐acetic acid was determined in brain tissue from rat and mouse with a gas chromatographic‐mass spectrometric method. Mouse brain contained 1.7‐3.2 nmol/g, depending on the strain. The concentration in cerebrum from Sprague‐Dawley rats was 1.2 nmol/g, whereas cerebellum contained 0.24 nmol/g. The concentration of tele ‐methylhistamine in mouse brain was 1.4‐2.2 nmol/g. The concentration of 1‐methylimidazole‐4‐acetic acid in rat brain after death did not change significantly during 2 h at room temperature.