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Conjugates of Dopamine and Serotonin in Ventriculocisternal Perfusates of the Cat
Author(s) -
Hammond Donna L.,
Yaksh Tony L.,
Tyce Gertrude M.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb12767.x
Subject(s) - dopamine , serotonin , chemistry , monoamine oxidase , oxidative deamination , conjugate , pargyline , biogenic amine , pharmacology , monoamine neurotransmitter , biochemistry , endocrinology , biology , enzyme , mathematical analysis , receptor , mathematics
The in vivo formation of acid‐hydrolyzable conjugates of dopamine and of serotonin (presumably dopamine‐ ‐O‐ ‐sulfate and serotonin‐ O ‐sulfate) in ventriculo‐ cisternal perfusions of the cat is described. Small amounts of these amine conjugates were detected under quiescent conditions and during evoked release of the parent amines. The amounts of conjugated dopamine in perfusate were increased during and immediately after the period in which release of dopamine was evoked, but were not affected by inhibition of monoamine oxidase. In contrast, the efflux of serotonin conjugate during the evoked release of serotonin was not increased unless monoamine oxidase was inhibited. The data suggest that conjugation of amines in the CNS may be of functional importance in their disposition either under conditions of augmented release or during inhibition of oxidative deamination.