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The Activity of 2′,3′‐Cyclic Nucleotide 3′‐Phosphohydrolase in the Corpus Callosum, Subcortical White Matter, and Spinal Cord in Infants Dying from Sudden Infant Death Syndrome
Author(s) -
Carey Eric M.,
Foster Peter C.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb12692.x
Subject(s) - corpus callosum , white matter , sudden infant death syndrome , spinal cord , myelin , respiratory distress , endocrinology , oligodendrocyte , medicine , pathology , central nervous system , biology , neuroscience , anesthesia , pediatrics , magnetic resonance imaging , radiology
The activity of 2′,3′‐cyclic nucleotide 3′‐phos‐phohydrolase (CNPase) has been determined in corpus callosum, subcortical white matter, and spinal cord of infants whose death was attributed to the sudden infant death syndrome (SIDS), and compared with enzyme activity in other cases in which the cause of death was not associated with respiratory distress. In nearly half the SIDS cases, CNPase activity and oligodendroglial cell numbers were reduced before the onset of myelination, but only in the corpus callosum. In other SIDS cases, enzyme activity and cell numbers were the same as in non‐SIDS cases. If the expression of CNPase activity reflects glioblast differentiation to oligodendrocytes with myelinating potential, then this transformation is abnormal in certain SIDS cases, as also evidenced in cases of prolonged neonatal respiratory insufficiency and gives rise to a subsequent deficit of myelin in the corpus callosum.