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Modifications of Synaptosomal Na + ‐K + ‐ATPase Activity During Vasogenic Brain Edema in the Rabbit
Author(s) -
Averet N.,
Rigoulet M.,
Cohadon F.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb09729.x
Subject(s) - ouabain , intracellular , chemistry , edema , brain edema , atpase , brain tissue , enzyme , endocrinology , medicine , biochemistry , sodium , organic chemistry
This study investigates the functioning of synaptosomal ouabain‐sensitive Na + ‐K + ‐ATPase in cold‐induced edema. During vasogenic brain edema development, the enzyme affinities for Na + and K + are progressively decreased paralleling the increase in the tissue water content, whereas maximal velocity of the reaction is not changed. On the basis of these data, it is likely that Na + ‐K + ‐ATPase impairment accounts for the intracellular uptake of water in this model of edema.