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Ethanolamine Accumulation by Photoreceptor Cells of the Rabbit Retina
Author(s) -
Pu Glen AWen,
Anderson Robert E.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb09715.x
Subject(s) - ethanolamine , choline , phosphatidylethanolamine , phospholipid , retina , biochemistry , biology , phosphatidylcholine , phosphorylation , chemistry , microbiology and biotechnology , membrane , neuroscience
The rabbit retina accumulates ethanolamine by an overall process that has a high affinity for ethanolamine. This process is different from the choline uptake, since ethanolamine accumulation was unaffected by high choline concentrations. Autoradiography identified the major site of high‐affinity uptake as the perinuclear region of the photoreceptor cells. Ethanolamine accumulated by the high‐affinity uptake was not used for neurotransmission by photoreceptor cells but was used to synthesize phosphatidylethanolamine. However, only a small percentage of the accumulated ethanolamine was converted into phospholipid. The rate of phosphorylation may contribute to control of phospholipid synthesis, since choline kinase activity is much greater than ethanolamine kinase activity in the rabbit retina.