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Spontaneous and Experimental Neuritis and the Distribution of the Myelin Protein P 2 in the Nervous System
Author(s) -
Kadlubowski M.,
Hughes R. A. C.,
Gregson N. A.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb09707.x
Subject(s) - spinal cord , peripheral nervous system , nervous system , central nervous system , grey matter , neuritis , myelin , nervous tissue , guinea pig , anatomy , pathology , peripheral , medicine , biology , white matter , neuroscience , endocrinology , magnetic resonance imaging , radiology
The P 2 contents of nervous tissues from the human, rabbit, guinea pig, and Lewis rat were measured by radioimmunoassay. The ventral spinal roots contained more P 2 than any other tissue. Human dorsal roots and peripheral nerves contained 41–65% of the amount in human ventral roots. Human olfactory and optic nerves and brain contained 1.1–2.7%, spinal cord, 2.8%, cranial nerve VIII, 11%, and cerebral grey matter, 0%. The relative amounts in the rabbit nervous system were similar except that the spinal cord contained 20% of the amount in the ventral roots. Qualitative estimates in the guinea pig showed that the spinal roots and peripheral nerves contained more P 2 than the spinal cord, and that none was present in the brain. In the Lewis rat, P 2 could be detected in the spinal roots and peripheral nerves but not in the CNS. The distribution of P 2 in the human nervous system parallels the incidence and severity of lesions in acute polyradiculoneuritis. It also explains the absence of any lesions in the CNS when experimental allergic neuritis is induced in the Lewis rat.