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Effect of Lesions of the Olfactory Bulb on the Levels of Amino Acids and Related Enzymes in the Olfactory Cortex of the Guinea Pig
Author(s) -
Sandberg M.,
Bradford H. F.,
Richards C. D.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb06709.x
Subject(s) - olfactory bulb , guinea pig , olfactory system , biology , piriform cortex , enzyme , amino acid , olfactory tubercle , neuroscience , biochemistry , anatomy , chemistry , central nervous system , endocrinology
Olfactory bulb removal and consequential degeneration of the lateral olfactory tract led to a decreasein the levels of glutaminase and malate dehydrogenase inthe ipsilateral olfactory cortex. These changes in enzyme activity may account for the well established decrease inthe levels of aspartate and glutamate in the olfactory cortex following ipsilateral bulbectomy. The level of glutamine synthetase, a glial marker enzyme, was slightly‐increased while the activities of glutamate decarboxylase, glutamate dehydrogenase, and glutamate oxaloacetic transaminase were unchanged.