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Phosphate Derivatives of Thiamine and Na+ Channel in Conducting Membranes
Author(s) -
Schoffeniels Ernest,
Dandrifosse Guy,
Bettendorff L.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb06706.x
Subject(s) - thiamine , membrane , phosphate , chemistry , biochemistry , biophysics , biology
The results show that thiamine derivatives are copurified with the specific proteins forming the Na+ channel in conducting membranes. Therefore, thiamine derivatives could well play a specific role in the molecular aspects of bioelectrogenesis, an interpretation that could help explain the neurological symptoms observed in human pathology as well as in animals experimentally rendered deficient in vitamin Bl.