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Concentrations of Homovanillic Acid and 5‐Hydroxyindoleacetic Acid in Cerebrospinal Fluid from Human Infants in the Perinatal Period
Author(s) -
Silverstein Faye S.,
Donn Steven,
Buchanan Karen,
Johnston Michael V.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb06109.x
Subject(s) - homovanillic acid , 5 hydroxyindoleacetic acid , cerebrospinal fluid , dopamine , serotonin , medicine , lumbar puncture , endocrinology , monoamine neurotransmitter , analysis of variance , receptor
Abstract To assess maturation of central serotonin and catecholamine pathways at birth, we measured lumbar CSF homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA), stable acid metabolites of dopamine and serotonin, using HPLC with electrochemical detection. CSFs from 57 neonates (38 premature and 19 at term) and 13 infants 1–6 months old were studied. HVA levels increased with maturity (p < 0.05; ANOVA), whereas, 5‐HIAA levels were similar in all these subjects. HVA/5‐HIAA ratios increased markedly from 1 ± 0.12 in the most premature neonates to 1.98 ± 0.17 in the older infants (p < 0.01; t test). There were no sex differences for these values.