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Biosynthesis of 5‐Aminopentanoic Acid and 2‐Piperidone from Cadaverine and 1‐Piperideine in Mouse
Author(s) -
Callery Patrick S.,
Geelhaar Linda A.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb06088.x
Subject(s) - cadaverine , chemistry , metabolite , biochemistry , stereochemistry , chromatography , putrescine , enzyme
1‐Piperideine, 5‐aminopentanoic acid, and its lactam, 2‐piperidone, were identified as metabolites of cadaverine in 10,000 g mouse liver supernatants to which diamine oxidase had been added. Both metabolites were also found when the cadaverine metabolite 1‐piperideine was incubated with the preparation which suggested that 1‐piperideine is an intermediate in the formation of 5‐ammopentanoic acid and 2‐piperidone. Identification of the metabolites was based on gas chromatography‐mass spectrometric analysis in comparison to authentic standards. Mouse brain homogenates converted 1‐piperideine to 5‐aminopentanoic acid. The results suggest that the metabolic fate of cadaverine may provide precursors of pharmacologically active analogues of GABA.