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S100a 0 (αα) Protein Is Present in Neurons of the Central and Peripheral Nervous System
Author(s) -
Isobe Toshiaki,
Takahashi Kiyoshi,
Okuyama Tsuneo
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb05415.x
Subject(s) - protein subunit , immunohistochemistry , cytoplasm , intracellular , biology , central nervous system , microbiology and biotechnology , neuroscience , biochemistry , immunology , gene
The cellular distribution of S100 subunits in human brain and peripheral nerves was studied by means of an immunohistochemical technique using antibodies specific to the a subunit or the β subunit of S100 protein. The results indicate that the distribution of the a subunit and the β subunit is different among cell types in the nervous tissue, and that neurons in the brain and peripheral nerves contain only the a subunit, or S100a 0 protein. The subunit distribution also appears to be different at an intracellular level, where the immunoreaction products for the a subunit show granular arrangement whereas those for the β subunit are found diffusely in the cytoplasm.